Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe

Table 2 List of most significant SNPs associated with SJS/TEN

SNP	Chr	Position Build 36	RiskAllele (Other Allele)	Risk Allele Frequency in Cases	Risk Allele Frequency in Controls	PC corrected Trend test^b	p-value^b	q-value^c	OddsRatio^d	95% CI^d	Pvalue of HW test	Annotation^a
rs2844665	6	31114834	C (T)	0.72	0.62	26.46	2.69 10^-7	1.48 10^-2	1.54	1.30-1.82	0.77	C6orf205 flanking_3UTR
rs3815087	6	31201566	A (G)	0.31	0.21	26.32	2.89 10^-7	1.54 10^-2	1.53	1.29-1.80	0.08	PSORS1C1 UTR
rs3130931	6	31242867	C (T)	0.77	0.69	24.41	7.78 10^-7	3.34 10^-2	1.54	1.29-1.84	0.66	POU5F1 Intron
rs3130501	6	31244432	G (A)	0.83	0.74	31.78	1.73 10^-8	0.22 10^-2	1.74	1.43-2.13	0.59	POU5F1 Intron
rs3094188	6	31250224	A (C)	0.72	0.63	30.75	2.93 10^-8	0.26 10^-2	1.59	1.34-1.88	0.06	POU5F1 Flanking_5UTR
rs9469003	6	31515807	C (T)	0.24	0.15	36.41	1.60 10^-9	0.04 10^-2	1.73	1.44-2.08	0.003	HCP5 flanking_5UTR

^a Annotations were obtained from the Illumina annotation file.
^b Results obtained using the test implemented in Eigenstrat
^c q-values (FDR adjusted p-values) were obtained by using the R package fdrtool [50].
^d Results obtained using plink logistic regression test accounting for the top 2 PC.

ISSN: 1750-1172