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Table 2 List of most significant SNPs associated with SJS/TEN

From: Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe

SNP Chr Position Build 36 RiskAllele (Other Allele) Risk Allele Frequency in Cases Risk Allele Frequency in Controls PC corrected Trend testb p-valueb q-valuec OddsRatiod 95% CId Pvalue of HW test Annotationa
rs2844665 6 31114834 C (T) 0.72 0.62 26.46 2.69 10-7 1.48 10-2 1.54 1.30-1.82 0.77 C6orf205
flanking_3UTR
rs3815087 6 31201566 A (G) 0.31 0.21 26.32 2.89 10-7 1.54 10-2 1.53 1.29-1.80 0.08 PSORS1C1
UTR
rs3130931 6 31242867 C (T) 0.77 0.69 24.41 7.78 10-7 3.34 10-2 1.54 1.29-1.84 0.66 POU5F1
Intron
rs3130501 6 31244432 G (A) 0.83 0.74 31.78 1.73 10-8 0.22 10-2 1.74 1.43-2.13 0.59 POU5F1
Intron
rs3094188 6 31250224 A (C) 0.72 0.63 30.75 2.93 10-8 0.26 10-2 1.59 1.34-1.88 0.06 POU5F1
Flanking_5UTR
rs9469003 6 31515807 C (T) 0.24 0.15 36.41 1.60 10-9 0.04 10-2 1.73 1.44-2.08 0.003 HCP5
flanking_5UTR
  1. a Annotations were obtained from the Illumina annotation file.
  2. b Results obtained using the test implemented in Eigenstrat
  3. c q-values (FDR adjusted p-values) were obtained by using the R package fdrtool [50].
  4. d Results obtained using plink logistic regression test accounting for the top 2 PC.