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Table 1 Characteristics of adults with at least two subcutaneous neurofibromas (cases) and controls

From: At-Risk Phenotype of Neurofibromatose-1 Patients: A Multicentre Case-Control Study

Clinical features Cases n = 106 Controls n = 102 p value*
Matching variables
Female gender 62 (59) 62 (61)  
Age (years) 41 (± 13) 41 (± 14)  
Clinical variables    
Familial case 56 (47) 56 (45) 0.76
No cutaneous neurofibromas 13 (12) 4 (4) 0.03
Plexiform neurofibromas 66 (62) 49 (48) 0.04
Large café-au-lait spots (number) 8.6 (± 4.8) 10.1 (± 10.1) 0.07
No freckles 21 (20) 12 (12) 0.11
Lisch nodules 48 (81) 45 (80) 0.89
Scoliosis 46 (43) 42 (41) 0.75
Headache 38 (36) 41 (40) 0.52
Epilepsy 2 (2) 2 (2) 0.97
Learning disabilities 58 (57) 52 (49) 0.26
  1. *p value obtained using chi-square test or Fisher exact or non-parametric Kruskal-Wallis test as appropriate
  2. Data are numbers (%) or means ± 1 standard deviation