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Table 2 Behavioural scores pre-and post-administration of OT in the placebo and OT groups; pre-administration score is the mean of the scores reported on the two days before administration; Early effect is the immediate score recorded the half-day following administration and late effect is the mean of the scores reported on the two days following administration (the immediate score recorded the half-day following administration was excluded).

From: Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients

Variable

Placebo Group

OT Group

P-value

Isolation tendencies

   

Pre-administration

-0.111 ± 0.296

-0.083 ± 0.289

0.580

Early effect

-0.250 ± 0.452

-0.083 ± 0.289

0.284

Late effect

-0.111 ± 0.217

0 ± 0

0.070

Sadness tendencies

   

Pre-administration

-0.208 ± 0.276

-0.194 ± 0.407

0.513

Early effect

-0.083 ± 0.289

-0.083 ± 0.289

>0.99

Late effect

-0.347 ± 0.379

-0.083 ± 0.289

0.021

Depressive tendencies

   

Pre-administration

-0.028 ± 0.096

-0.056 ± 0.192

0.952

Early effect

0 ± 0

0 ± 0

>0.99

Late effect

-0.125 ± 0.311

0 ± 0

0.149

Self-depreciation

   

Pre-administration

-0.028 ± 0.096

-0.056 ± 0.192

0.952

Early effect

0 ± 0

-0.083 ± 0.289

0.317

Late effect

-0.083 ± 0.289

0 ± 0

0.317

Self-mutilation

   

Pre-administration

-0.069 ± 0.166

-0.278 ± 0.468

0.271

Early effect

-0.083 ± 0.289

-0.083 ± 0.289

>0.99

Late effect

-0.028 ± 0.096

-0.083 ± 0.195

0.482

Conflicts with others

   

Pre-administration

-0.208 ± 0.276

-0.319 ± 0.359

0.467

Early effect

-0.250 ± 0.452

0 ± 0

0.07

Late effect

-0.125 ± 0.237

-0.111 ± 0.205

0.939

Disruptive behaviour

   

Pre-administration

-0.361 ± 0.354

-0.431 ± 0.344

0.744

Early effect

-0.250 ± 0.452

-0.167 ± 0.389

0.623

Late effect

-0.306 ± 0.382

-0.042 ± 0.144

0.031

Interest in friendship

   

Pre-administration

0.806 ± 0.324

0.875 ± 0.433

0.349

Early effect

0.833 ± 0.389

0.917 ± 0.515

0.683

Late effect

0.778 ± 0.410

1.028 ± 0.234

0.088

Interest in love affairs

   

Pre-administration

0.847 ± 0.579

0.972 ± 0.531

0.589

Early effect

0.833 ± 0.389

0.917 ± 0.515

0.683

Late effect

0.847 ± 0.441

0.903 ± 0.411

0.714

Trust in others

   

Pre-administration

0.833 ± 0.389

0.861 ± 0.332

0.929

Early effect

0.917 ± 0.289

0.833 ± 0.389

0.546

Late effect

0.764 ± 0.366

1.028 ± 0.096

0.023