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Table 2 Behavioural scores pre-and post-administration of OT in the placebo and OT groups; pre-administration score is the mean of the scores reported on the two days before administration; Early effect is the immediate score recorded the half-day following administration and late effect is the mean of the scores reported on the two days following administration (the immediate score recorded the half-day following administration was excluded).

From: Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients

Variable Placebo Group OT Group P-value
Isolation tendencies    
Pre-administration -0.111 ± 0.296 -0.083 ± 0.289 0.580
Early effect -0.250 ± 0.452 -0.083 ± 0.289 0.284
Late effect -0.111 ± 0.217 0 ± 0 0.070
Sadness tendencies    
Pre-administration -0.208 ± 0.276 -0.194 ± 0.407 0.513
Early effect -0.083 ± 0.289 -0.083 ± 0.289 >0.99
Late effect -0.347 ± 0.379 -0.083 ± 0.289 0.021
Depressive tendencies    
Pre-administration -0.028 ± 0.096 -0.056 ± 0.192 0.952
Early effect 0 ± 0 0 ± 0 >0.99
Late effect -0.125 ± 0.311 0 ± 0 0.149
Self-depreciation    
Pre-administration -0.028 ± 0.096 -0.056 ± 0.192 0.952
Early effect 0 ± 0 -0.083 ± 0.289 0.317
Late effect -0.083 ± 0.289 0 ± 0 0.317
Self-mutilation    
Pre-administration -0.069 ± 0.166 -0.278 ± 0.468 0.271
Early effect -0.083 ± 0.289 -0.083 ± 0.289 >0.99
Late effect -0.028 ± 0.096 -0.083 ± 0.195 0.482
Conflicts with others    
Pre-administration -0.208 ± 0.276 -0.319 ± 0.359 0.467
Early effect -0.250 ± 0.452 0 ± 0 0.07
Late effect -0.125 ± 0.237 -0.111 ± 0.205 0.939
Disruptive behaviour    
Pre-administration -0.361 ± 0.354 -0.431 ± 0.344 0.744
Early effect -0.250 ± 0.452 -0.167 ± 0.389 0.623
Late effect -0.306 ± 0.382 -0.042 ± 0.144 0.031
Interest in friendship    
Pre-administration 0.806 ± 0.324 0.875 ± 0.433 0.349
Early effect 0.833 ± 0.389 0.917 ± 0.515 0.683
Late effect 0.778 ± 0.410 1.028 ± 0.234 0.088
Interest in love affairs    
Pre-administration 0.847 ± 0.579 0.972 ± 0.531 0.589
Early effect 0.833 ± 0.389 0.917 ± 0.515 0.683
Late effect 0.847 ± 0.441 0.903 ± 0.411 0.714
Trust in others    
Pre-administration 0.833 ± 0.389 0.861 ± 0.332 0.929
Early effect 0.917 ± 0.289 0.833 ± 0.389 0.546
Late effect 0.764 ± 0.366 1.028 ± 0.096 0.023