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Table 4 Parameter estimates of the population HbF% model

From: Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell anemia patients, a basis for optimizing the dosing regimen

Parameters Typical values (95% CI) SD of IIV (95% CI) Interindividual CV
Kin (%/day) 0.071 (0.055 - 0.094) 0.585 (0.472 - 0.681) 63%
Kout (day-1) 0.013 (0.010 - 0.019) 0.486 (0.334 - 0.602) 52%
LImax (unitless) 0.276 (-0.081 - 0.644)
(Imax = 0.569 (0.48 - 0.656))
1.44 (1.07 - 1.97) 27%
θΔMCV(day-1) 1.37 (0.95 - 1.76)   
SD of proportional residual error 0.142 (0.119 - 0.162)   
Correlation (ηKout, ηImax) 0.892   
  1. CI: confidence intervals, obtained by bootstrap (n = 1000), SD: standard deviation, IIV: interindividual variability, CV: the apparent coefficient of variation of interindividual variability.