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Table 4 Parameter estimates of the population HbF% model

From: Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell anemia patients, a basis for optimizing the dosing regimen

Parameters

Typical values (95% CI)

SD of IIV (95% CI)

Interindividual CV

Kin (%/day)

0.071 (0.055 - 0.094)

0.585 (0.472 - 0.681)

63%

Kout (day-1)

0.013 (0.010 - 0.019)

0.486 (0.334 - 0.602)

52%

LImax (unitless)

0.276 (-0.081 - 0.644)

(Imax = 0.569 (0.48 - 0.656))

1.44 (1.07 - 1.97)

27%

θΔMCV(day-1)

1.37 (0.95 - 1.76)

  

SD of proportional residual error

0.142 (0.119 - 0.162)

  

Correlation (ηKout, ηImax)

0.892

  
  1. CI: confidence intervals, obtained by bootstrap (n = 1000), SD: standard deviation, IIV: interindividual variability, CV: the apparent coefficient of variation of interindividual variability.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172