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Table 2 Treatments of patients with the Schnitzler syndrome before the use of anakinra

From: The Schnitzler syndrome

Treatment Comment
Steroids Suspensive, but usually requiring a high daily dosis (>40 mg equivalent of prednisolone) to achieve improvement
Non steroid anti-inflammatory drugs, most notably ibuprofen Transient amelioration of fever and pain
Immunosuppressive drugs, including methotrexate, azathioprine, cyclophosphamide Usually ineffective
Colchicine, dapsone Transient improvement
Thalidomide Anecdotic reports of efficiency
TNF-blocking agents Ineffective
Immunoabsorption Only a single report
Intravenous immunoglobulins Ineffective
Rituximab Ineffective
Anti-histamines Usually ineffective, even on the skin rash
Phototherapy Transient amelioration of skin rash
Peflacine Efficient in some patients; recurrence if treatment is stopped.
Anakinra Complete and sustained remission of all symptoms; recurrence if treatment is stopped