Table 2 Treatments of patients with the Schnitzler syndrome before the use of anakinra
From: The Schnitzler syndrome
Treatment | Comment |
|---|---|
Steroids | Suspensive, but usually requiring a high daily dosis (>40 mg equivalent of prednisolone) to achieve improvement |
Non steroid anti-inflammatory drugs, most notably ibuprofen | Transient amelioration of fever and pain |
Immunosuppressive drugs, including methotrexate, azathioprine, cyclophosphamide | Usually ineffective |
Colchicine, dapsone | Transient improvement |
Thalidomide | Anecdotic reports of efficiency |
TNF-blocking agents | Ineffective |
Immunoabsorption | Only a single report |
Intravenous immunoglobulins | Ineffective |
Rituximab | Ineffective |
Anti-histamines | Usually ineffective, even on the skin rash |
Phototherapy | Transient amelioration of skin rash |
Peflacine | Efficient in some patients; recurrence if treatment is stopped. |
Anakinra | Complete and sustained remission of all symptoms; recurrence if treatment is stopped |