Pancreatic histology. Hematoxylin phloxin saffron stain (× 400). Acinar structures are reduced in number and exocrine cells show abundant cytoplasm and hyperacidophilic material in WRS patient. Langerhans islets are smaller in WRS than in normal control. WRS: WRS patient, N: normal control. (histological study performed by R. Bouvier and S. Collardeau-Frachon, Lyon).