Interstitial lung diseases in children

Table 1 Systemic disease-associated interstitial lung diseases: suggested clinical features and serotypes

CONNESTIVE TISSUE DISEASE	MAIN CLINICAL FEATURES	MAIN SEROLOGICAL FEATURES	HLA PREDISPOSITION
Rheumatoid arthritis	Arthralgia	RF IgM and IgA Anti-CCP Anti-keratin	HLA-DR SE
Systemic sclerosis	Sclerodactyly	ANA-SSc Anti-centromere Anti-topoisomerase I (Scl70) and II Anti-RNA polymerase	HLA-DR3, HLA-DPB1
Systemic lupus erythematosus	Skin rash Arthralgia Glomerulonephritis	ANA Anti-native DNA Anti-nucleosome Anti-Sm, RNP, SSA, SSB Anti-ribosome CIC
Sjögren syndrome	Xerostomia Serophtalmia	ANA Anti-SSA, SSB RF Anti-RNP
Dermatomyositis and polymyositis	Muscle weakness Skin rash	ANA Anti-Jo1 Anti-Mi2 Anti-SRP C-ADM-140
Ankylosing Spondylitis	Bony ankylosis		HLA-B27
Mixed connective tissue disease	Raynaud phenomenon	Anti-U1-RNP
PULMONARY VASCULITIS	MAIN CLINICAL FEATURES	MAIN SEROLOGICAL FEATURES	HLA PREDISPOSITION
Wegener's granulomatosis	Glomerulonephritis Sinusitis	c-ANCA PR3
Churg-Strauss syndrome	Asthma	p-ANCA
Microscopic polyangitis	Glomerulonephritis Sinusitis Skin involvement	p-ANCA
Goodpasture syndrome	Glomerulonephritis	anti-GMB	HLA-DRB1*1501
Henoch-Schönlein purpura	Purpura Glomerulonephritis	IgA deposition	HLA-DRB1
Cryoglobulinemic vasculitis	Skin involvment Hepatitis Glomerulonephritis	Cryoglobulin

Abbreviations: Rheumatoid factor (RF), Immunoglobulin (Ig), Human leucocyte Antigen (HLA), Anticyclic citrullinated peptide (anti-CCP), Antinuclear antibodies (ANA), Systemic sclerosis (SSc), Smith (Sm), ribonucleoprotein (RNP), circulating immune complex (CIC), anti-histidyl-t-RNA synthetase (Jo1), signal recognition particle (SRP), anti-U1-ribonucleoprotein antibody (anti-U1-RNP Ab); Cytoplasmic-staining (c) or Perinuclear-staining (p) anti-neutrophil cytoplasmic antibody (ANCA), anti-glomerular basement membrane (anti-GBM)

ISSN: 1750-1172