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Table 1 Systemic disease-associated interstitial lung diseases: suggested clinical features and serotypes

From: Interstitial lung diseases in children

CONNESTIVE TISSUE DISEASE MAIN CLINICAL
FEATURES
MAIN SEROLOGICAL
FEATURES
HLA
PREDISPOSITION
Rheumatoid arthritis Arthralgia RF IgM and IgA
Anti-CCP
Anti-keratin
HLA-DR SE
Systemic sclerosis Sclerodactyly ANA-SSc
Anti-centromere
Anti-topoisomerase I
(Scl70) and II
Anti-RNA polymerase
HLA-DR3, HLA-DPB1
Systemic lupus
erythematosus
Skin rash
Arthralgia
Glomerulonephritis
ANA
Anti-native DNA
Anti-nucleosome
Anti-Sm, RNP,
SSA, SSB
Anti-ribosome
CIC
 
Sjögren syndrome Xerostomia
Serophtalmia
ANA
Anti-SSA, SSB
RF
Anti-RNP
 
Dermatomyositis
and polymyositis
Muscle weakness
Skin rash
ANA
Anti-Jo1
Anti-Mi2
Anti-SRP
C-ADM-140
 
Ankylosing
Spondylitis
Bony ankylosis   HLA-B27
Mixed connective
tissue disease
Raynaud phenomenon Anti-U1-RNP  
PULMONARY
VASCULITIS
MAIN CLINICAL
FEATURES
MAIN SEROLOGICAL
FEATURES
HLA
PREDISPOSITION
Wegener's
granulomatosis
Glomerulonephritis
Sinusitis
c-ANCA PR3  
Churg-Strauss
syndrome
Asthma p-ANCA  
Microscopic
polyangitis
Glomerulonephritis
Sinusitis
Skin involvement
p-ANCA  
Goodpasture
syndrome
Glomerulonephritis anti-GMB HLA-DRB1*1501
Henoch-Schönlein
purpura
Purpura
Glomerulonephritis
IgA deposition HLA-DRB1
Cryoglobulinemic
vasculitis
Skin involvment
Hepatitis
Glomerulonephritis
Cryoglobulin  
  1. Abbreviations: Rheumatoid factor (RF), Immunoglobulin (Ig), Human leucocyte Antigen (HLA), Anticyclic citrullinated peptide (anti-CCP), Antinuclear antibodies (ANA), Systemic sclerosis (SSc), Smith (Sm), ribonucleoprotein (RNP), circulating immune complex (CIC), anti-histidyl-t-RNA synthetase (Jo1), signal recognition particle (SRP), anti-U1-ribonucleoprotein antibody (anti-U1-RNP Ab); Cytoplasmic-staining (c) or Perinuclear-staining (p) anti-neutrophil cytoplasmic antibody (ANCA), anti-glomerular basement membrane (anti-GBM)