Table 1 Common types of beta-thalassemia: severity and ethnic distribution.
From: Beta-thalassemia
Population | β-gene mutation | Severity |
|---|---|---|
Indian | -619 del | β0 |
Mediterranean | -101 C→T | β++ |
Black | -88 C→T | β++ |
Mediterranean; African | -87 C→G | β++ |
Japanese | -31 A→G | β++ |
African | -29 A→G | β++ |
Southeast Asian | -28 A→C | β++ |
Mediterranean; Asian Indian | IVS1-nt1 G→A | β0 |
East Asian; Asian Indian | IVS1-nt5 G→C | β0 |
Mediterranean | IVS1-nt6 T→C | β+/++ |
Mediterranean | IVS1-nt110 G→A | β+ |
Chinese | IVS2-nt654 C→T | β+ |
Mediterranean | IVS2-nt745 C→G | β+ |
Mediterranean | codon 39 C→T | β0 |
Mediterranean | codon 5 -CT | β0 |
Mediterranean; African-American | codon 6 -A | β0 |
Southeast Asian | codon 41/42 -TTCT | β0 |
African-American | AATAAA to AACAAA | β++ |
Mediterranean | AATAAA to AATGAA | β++ |
Mediterranean | codon 27 G→T Hb (Hb Knossos) | β++ |
Southeast Asian | codon 79 G>A (Hb E) | β++ |
Malaysia | Codon 19 G>A (Hb Malay) | Â |