Figure 5
From: Hereditary alpha-1-antitrypsin deficiency and its clinical consequences
Structure of alpha-1-antitrypsin: 3 β-sheets and 8 α-helixes. The reactive loop site contains the neutrophil elastase binding site with a methionine residue. Reprinted from Janciauskiene S. Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles. Biochim Biophys Acta, 2001, 1535:221-35. Copyright © 2001, with permission from Elsevier.