Skin features of LS individual at different ages. 2A: Numerous lentigines in the upper part of the trunk in a 2 year old child with a PTPN11 gene mutation. 2B. Lentigines and a large cafè-au-lait spot (28 year-old female patient). 2C. A 28 year old female patient with thousands of lentigines scattered all over the neck and back. Note the pterigium colli. 2D. Multiple lentigines on the lower leg (37 year-old male patient).