Adaptive design methods in clinical trials – a review

Table 1 Summary of simulation results for the designs

Method	Assumed True MTD	Mean Predicted MTD	Mean Number of Patient	Mean Number of DLTs
3+3 TER	100	86.7	14.9	2.8
CRM	100	99.2	13.4	2.8
3+3 TER	150	125	19.4	2.9
CRM	150	141	15.5	2.5
3+3 TER	200	169	22.4	2.8
CRM	200	186	16.8	2.2

ISSN: 1750-1172