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Orphanet Journal of Rare Diseases
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Table 1 Summary of simulation results for the designs
From:
Adaptive design methods in clinical trials – a review
Method
Assumed True MTD
Mean Predicted MTD
Mean Number of Patient
Mean Number of DLTs
3+3 TER
100
86.7
14.9
2.8
CRM
100
99.2
13.4
2.8
3+3 TER
150
125
19.4
2.9
CRM
150
141
15.5
2.5
3+3 TER
200
169
22.4
2.8
CRM
200
186
16.8
2.2
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