Skip to main content
  • Poster presentation
  • Open access
  • Published:

Specific ocular changes in TTR Met30-FAP after liver transplantation


To report ocular manifestations in Portuguese TTR Met30 FAP patients submitted to liver transplant (LT).


Retrospective observational consecutive case series of 78 LT recipients, observed by one ophthalmologist (FN) between January 2007 and July 2015. Demographic data, age at beginning of disease, period of evolution of disease, ophthalmological alterations and ocular surgeries (glaucoma surgery and vitrectomy) were evaluated. Patients were divided in three groups according to date of LT: less than 5 years (group 1); between 5 and 10 years (group 2) and more than 10 years (group 3).


Thirty-six patients were male. Twelve, 32 and 34 patients belong to group 1, 2 and 3 respectively. The mean age of patients was 41 years (group 1), 44 years (group 2) and 50 years (group 3). Symptoms and signs of dry eye were present in 33% (group1), 56% (group 2) and 62% (group 3) of patients. Amyloid deposits on pupillary border were observed in 16%, 27% and 41% of eyes according to each group. Scalloped pupil was present in 16%, 25% and 36% of cases, respectively. Amyloid vitreous opacities could be seen in 33%, 40% and 59% of eyes. Vitrectomy and glaucoma surgery was performed in 19 and 24 eyes of group 3, respectively.


The prevalence of specific ocular changes increase with time after LT. The need of vitrectomy or glaucoma surgery is common 10 years after LT. Regular ophthalmological evaluation of FAP patients submitted to LT is important to accurately treat sight-threatening manifestations.

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ferreira, N., Dias, D., Vilas-Boas, C. et al. Specific ocular changes in TTR Met30-FAP after liver transplantation. Orphanet J Rare Dis 10 (Suppl 1), P64 (2015).

Download citation

  • Published:

  • DOI: