Characteristics | Non-TMP-SMZ group n = 112 | TMP-SMZ group n = 195 | Total n = 307 | P values |
---|---|---|---|---|
Sex, no. (%) | 0.876c | |||
 Male | 61 (54.5) | 108 (55.4) | 169 (55.0) |  |
 Female | 51 (45.5) | 87 (44.6) | 138 (45.0) |  |
Age (y) | 0.820d | |||
 Mean (range) | 5.1 (0.1–14.0) | 5.0 (0.1–14.0) | 5.1 (0.1–14.0) |  |
 Median (IQR) | 5.0 (1.5–7.8) | 5.0 (2.0–8.0) | 5.0 (1.8–8.0) |  |
Weight (kg) | 0.749d | |||
 Mean (range) | 18.4 (3.6–45.0) | 18.4 (3.5–50.0) | 18.4 (3.5–50.0) |  |
 Median (IQR) | 18.0 (11.1–24.0) | 18.0 (11.6–24.0) | 18.0 (11.5–24.0) |  |
Topography | 1.000e | |||
 Head and neck | 23 (20.5) | 41 (21.0) | 64 (20.8) |  |
 Limbs | 61 (54.5) | 106 (54.4) | 167 (54.4) |  |
 Upper | 22 (19.6) | 37 (19.0) | 59 (19.2) |  |
 Lower | 39 (34.8) | 69 (35.4) | 108 (35.2) |  |
 Trunk | 28 (25.0) | 48 (24.6) | 76 (24.8) |  |
Diagnosis, no. (%) | 0.982e | |||
 Vascular tumors | 47 (42.0) | 92 (47.2) | 139 (45.3) |  |
 Kaposiform hemangioendothelioma | 40 (35.7) | 81 (41.5) | 121 (39.4) |  |
 Tufted angioma | 7 (6.3) | 11 (5.6) | 18 (5.9) |  |
 Vascular malformations | 65 (58.0) | 103 (52.8) | 168 (54.7) |  |
 Venous malformation | 22 (19.6) | 35 (17.9) | 57 (18.6) |  |
 Arteriovenous malformation | 1 (0.9) | 5 (2.6) | 6 (2.0) |  |
 Lymphatic malformation | 18 (16.1) | 31 (15.9) | 49 (16.0) |  |
 Combined vascular malformation | 16 (14.3) | 22 (11.3) | 38 (12.4) |  |
 Vascular malformation associated with other anomalies | 8 (7.1) | 10 (5.1) | 18 (5.9) |  |
Previous therapies, no. (%)a | 81 (72.3) | 152 (77.9) | 233 (75.9) | 0.217e |
 Partial resection | 32 (28.6) | 46 (23.6) | 78 (25.4) |  |
 Sclerotherapy | 23 (20.5) | 39 (20.0) | 62 (20.2) |  |
 Embolization | 16 (14.3) | 22 (11.3) | 38 (12.4) |  |
 Laser | 8 (7.1) | 15 (7.7) | 23 (7.5) |  |
 Medical therapies | 41 (36.6) | 60 (30.8) | 101 (32.9) |  |
 Propranolol | 16 (14.3) | 21 (18.8) | 37 (12.1) |  |
 Corticosteroids | 26 (23.2) | 37 (33.0) | 63 (20.5) |  |
 Vincristine | 5 (4.5) | 8 (4.1) | 13 (4.2) |  |
 Supportive care treatmentsb | 29 (25.9) | 40 (20.5) | 69 (22.5) |  |
Disease activity | 0.526d | |||
 Mean (range) | 2.9 (1.0–4.0) | 2.8 (1.0–4.0) | 2.8 (1.0–4.0) |  |
 Median (IQR) | 3.0 (2.0–3.0) | 3.0 (2.0–3.0) | 3.0 (2.0–3.0) |  |