Table 2 Clinical and biochemical features of 42 patients with X-linked AHC
|  | Infantile-onset (n = 31) | Childhood-onset (n = 11) | P value | ||
|---|---|---|---|---|---|
| Â | n (%) | Value | n (%) | Value | |
Hyperpigmentation | 28 (90%) | – | 10 (91%) | – | 1.0000 |
Vomiting/diarrhoea | 12 (39%) | – | 8 (73%) | – | 0.0523 |
Failure to thrive | 11 (35%) | – | 2 (18%) | – | 0.4922 |
Convulsions | 7 (23%) | – | 0 (0%) | – | 0.2093 |
Increased ACTH (pg/ml) | 31 (100%) | – | 11 (100%) | – | – |
Decreased cortisol (nmol/L) | 27 (87%) | 65.1 (22.2–144.1) | 10 (91%) | 56.0 (19.3–125.0) | 0.7565 |
Hyponatremia (mmol/L) | 25 (81%) | 125.6 ± 9.3 | 7 (64%) | 129.9 ± 6.9 | 0.1182 |
Hyperkalaemia (mmol/L) | 23 (74%) | 6.3 ± 1.4 | 6 (55%) | 5.1 ± 0.9 | 0.0033 |