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Table 1 Heterogeneity and pleiotropy tests of instrument effects

From: Hypertension, antihypertensive drugs, and age at onset of Huntington’s disease

Exposure

N SNPs

Heterogeneity analysis

Pleiotropy analysis

Method

Q

Degree of

freedom

P

Method

Egger intercept

SE

P

SBP

435

MR Egger

435.9

433

0.452

MR Egger intercept

-0.004

0.016

0.793

  

IVW

436.0

434

0.464

MR-PRESSO

Global test

  

0.462

DBP

439

MR Egger

437.3

437

0.487

MR Egger intercept

0.013

0.015

0.386

  

IVW

438.1

438

0.490

MR-PRESSO

Global test

  

0.489

BB (LD threshold, r2 < 0.4)

8

MR Egger

2.6

6

0.856

MR Egger intercept

-0.129

0.193

0.528

 

IVW

3.1

7

0.879

MR-PRESSO

Global test

  

0.889

CCB (LD threshold, r2 < 0.4)

58

MR Egger

52.9

56

0.594

MR Egger intercept

0.065

0.051

0.207

 

IVW

54.5

57

0.569

MR-PRESSO

Global test

  

0.616

BB(LD threshold, r2 < 0.2)

7

MR Egger

2.0

5

0.852

MR Egger intercept

-0.115

0.194

0.580

 

IVW

2.3

6

0.887

MR-PRESSO

Global test

  

0.884

CCB(LD threshold, r2 < 0.2)

30

MR Egger

33.0

28

0.236

MR Egger intercept

0.017

0.072

0.813

 

IVW

33.1

29

0.276

MR-PRESSO

Global test

  

0.303

  1. SNP: single nucleotide polymorphism; MR: Mendelian randomization; IVW: inverse variance weighted; SBP: systolic blood pressure; DBP: diastolic blood pressure; CCB: calcium channel blocker; BB: β-blockers; SE: standard error