Table 3 Bivariate analysis to identify variables associated with the presence of a non-invasive diagnosis of significant hepatic fibrosis in patients with Ataxia-telangiectasia

Age

years

11.1 ± 4.2^c

27.2 ± 4.3

 < 0.001^a

BMI

kg/m²

14.8 (11.8–26.8)

20.8 (10.6–24.1)

0.118^b

Fat mass

%

17.9 ± 7.6

20.4 ± 5.4

0.553^a

MUAMC

mm

169.8 ± 42.8

240.8 ± 6.9

 < 0.001^a

WC

cm

54.5 (47.0–90.0)

78.0 (68.0–82.0)

0.008^b

WHtR

–

0.44 ± 0.06

0.49 ± 0.03

0.098^a

ICARS

points

49.7 ± 20.1

76.0 ± 7.7

0.009^a

Platelets count

10³/mm³

382 ± 100.5

266 ± 85.5

0.027^a

Albumin

g/dL

4.5 ± 0.3

4.0 ± 0.7

0.019^a

TC

mg/dL

167.9 (119.7–247.0)^d

180.1 (172.4–289.5)

0.154^b

LDL-c

mg/dL

101.7 (69.0–179.2)

130.0 (102.4–198.9)

0.049^b

HDL-c

mg/dL

47,3 ± 12,6

30.9 ± 10.1

0.013^a

TG

mg/dL

77.1 (35.0–196.7)

110.4 (53.4–331.0)

0.103^b

NHDL-c

mg/dL

115.5 (76.0–189.0)

152.1 (131.0–265.1)

0.067^b

AST

U/L

29.9 (16.6–74.3)

75.5 (46.9–82.3)

0.001^b

ALT

U/L

20.7 (11.4–73.4)

89.4 (32.3–144.5)

0.002^b

GGT

U/L

26.0 (7.0–102.0)

259.0 (108.0–612.0)

0.001^b

ALKP

U/L

230.5 (113.0–497.2)

176.7 (111.2–355.0)

0.684^b

CK-18

mIU/mL

252.8 (39.2–741.1)

191.4 (21.4–333.8)

0.374^b

AFP

UL/mL

281.9 ± 177.8

240.4 ± 133.9

0.632^a

Ferritin

ng/mL

82.3 (29.0–256.0)

419.0 (303.0–1538.0)

0.001^b

hs-CRP

mg/L

1.0 (0.39–9.8)

2.2 (0.20–53.1)

0.424^b

TNF-alpha

pg/mL

139.8 ± 8.5

142.0 ± 14.9

0.768^a

Adiponectin

µg/mL

7.0 ± 3.9

3.5 ± 2.9

0.084^a

SAA

ng/mL

11.3 (9.0–147.2)

20.4 (9.0–73.7)

0.111^b

Fasting glucose

mg/dL

85.7 ± 9.3

90.7 ± 17.9

0.628^a

120-min glycemia

mg/dL

90.2 ± 22.3

224.5 ± 84.8

0.049^a

HOMA-IR

–

1.4 (0.08–4.5)

6.9 (1.4–20.9)

0.060^b

HOMA-AD

–

4.1 (0.25–110.0)

108.1 (6.9–213.9)

0.016^b

Matsuda index

–

9.2 (1.5–81.3)

3.3 (0,6–4.5)

0.044^b