Fig. 2From: The Metreleptin Effectiveness and Safety Registry (MEASuRE): concept, design and challengesThe history of the MEASuRE including the key protocol changes MEASuRE was initiated as a US FDA-mandated pharmacovigilance program. The EMA ECLip, European Consortium of Lipodystrophies; EMA, European Medicines Agency; FDA, Food & Drug Administration; MEASuRE, Metreleptin Efficacy And Safety RegistryBack to article page