French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes

Box 5 Main discriminating features between lymphocytic HES and angioimmunoblastic T-cell lymphoma

	L-HES	AITL
General signs	Absent	Present (or initially fluctuating in some cases)
Tumor syndrome	Moderate	Prominent
Polyclonal hypergammaglobulinemia	≈ 50%	50–80%
CRP	Normal	Elevated
Laboratory markers of autoimmunity	Absent	Possible
Hypermetabolism on PET-CT	Possible	Present
Histological findings
CD10	Negative	Positive
CXCL13	Negative	Positive
PD1	Negative	Positive

ISSN: 1750-1172