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Box 1 Definition of eosinophilia, HE and HES (adapted from Valent et al. J Allergy Clin Immunol [1]; and Valent et al. Allergy [3])

From: French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes

Condition

Definition

Blood eosinophilia

Eosinophil count between 0.5 and 1.5 × 109/L eosinophils

Hypereosinophilia (HE)

Eosinophil count > 1.5 × 109/L on two occasions one month apart and/or tissue eosinophilia (as defined in “Definition of HES-related organ involvement” section)

Hypereosinophilic syndrome (HES)

Blood HE AND

Organ damage or dysfunction caused by tissue eosinophils (as defined in “Definition of HES-related organ involvement” Section), AND

Exclusion of other possible causes of organ dysfunction

HES/organ-specific eosinophilic disease

Blood and/or tissue eosinophilia AND

Single-organ/tract involvement

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172