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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Fig. 4

Effect of α-LA treatment on 4′-phosphopantetheinyl proteins expression levels. a Control and PKAN fibroblasts (P1, P2, P3) were treated with α-LA at 10 μM for twenty days. Protein extracts were separated on a SDS polyacrylamide gel and immunostained with antibodies against mtACP, ALDH1L2, AASS, FAS and AASDHPPT. Actin was used as a loading control. (b) Densitometry of Western blotting. *p < 0.05, **p < 0.005, ***p < 0.001 ****p < 0.0001 between PKAN patients and controls. #p < 0.05, ##p < 0.005, ###p < 0.001 ####p < 0.0001 between untreated and treated fibroblasts. A.U., arbitrary units

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