Fig. 2From: Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levelsDose–response effect of α-LA on PANK2 and mtACP protein expression levels. a Controls (C1, C2) and patient P1 fibroblasts were treated with increasing concentrations of lipoic acid for 20 days. PANK2 and mtACP protein expression levels of P1 levels were analysed by Western blotting. Actin was used as loading control. b Densitometry of the Western blotting of PANK2 and mtACP. Data represent the mean ± SD of three separate experiments. *p < 0.05, ***p < 0.001 between PKAN patients and controls. #p < 0.05 and ##p < 0.005 between untreated and treated fibroblasts. A.U., arbitrary unitsBack to article page