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Fig. 13 | Orphanet Journal of Rare Diseases

Fig. 13

From: Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Fig. 13

Effect of α-LA on iron accumulation in PKAN induced neurons (iNs). Control and PKAN iNs (P1) were treated with α-LA at 10 μM for 15 days a Representative images of iron accumulation by Prussian Blue staining in α-LA treated and untreated control and PKAN iNs. Scale bar = 15 μm. b Quantification of iron levels by FIJI-ImageJ. iNs showed positive immunoreactivity against Tau. Data represent the mean ± SD two separate experiment (50 cell images for each condition). **p < 0.01between PKAN patients and controls. #p < 0.05 between untreated and treated fibroblasts. A.U., arbitrary units

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172