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Fig. 11 | Orphanet Journal of Rare Diseases

Fig. 11

From: Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Fig. 11

Effect of α-LA treatment on lipofuscin accumulation. Control and PKAN fibroblasts (P1, P2, P3) were treated with α-LA at 10 μM for 20 days. a Representative images of lipofuscin staining by SBB of untreated and treated control and three PKAN patient fibroblasts. Scale bar = 20 μm. b SBB staining quantification. Data represent the mean ± SD of three separate experiments (50 cell images for each condition). *p < 0.05, **p < 0.05, ****p < 0.001 between PKAN patients and controls. #p < 0.05 between untreated and treated fibroblasts. A.U., arbitrary units

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