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Table 7 Binary logistic regression for SIRT1 rs3818292, rs3758391, between ON patients with MS and the control group

From: The role of SIRT1 level and SIRT1 gene polymorphisms in optic neuritis patients with multiple sclerosis

Polymorphism

Model

Genotype

OR (95% CI)

p-value

AIC

rs3818292

Codominant

A/A

1

0.123

1

185,292

A/G

2.087 (0.820–5.312)

G/G

Dominant

A/A

1

0.225

185.362

A/G + G/G

1.771 (0.703–4.457)

Recessive

AA + A/G

1

1

185.462

G/G

Overdominant

A/A + G/G

1

0.110

184.409

A/G

2.141 (0.841–5449)

Additive

G

1.364 (0617–3.013)

0.443

186.178

rs3758391

Codominant

C/C

1

0.082

0.926

181.417

C/T

0.321 (0.090–1.153)

T/T

0.994 (0.284–3.145)

Dominant

C/C

1

0.010

179.425

C/T + T/T

2.970 (1,303–6.770)

Recessive

C/C + C/T

1

0.334

185.879

T/T

1.769 (0.556–5.630)

Overdominant

C/C + T/T

1

0.032

182.090

C/T

2.235 (1.075–5.030)

Additive

T

1.199 (1.143–3450)

0.015

178.919

rs7895833

Codominant

A/A

1

 < 0.001

0.954

175.665

A/G

4.347 (1.953–9.677)

G/G

1.064 (0.128–8.836)

Dominant

A/A

1

0.001

176.008

A/G + G/G

3.679 (1.685–8.033)

Recessive

AA + A/G

1

0.643

186.483

G/G

0.612 (0.077–4.882)

Overdominant

A/A + G/G

1

 < 0.001

173.668

A/G

4.328 (1.972–9.499)

Additive

G

2.058 (1.162–3.645)

0.013

181.025

  1. p-value—significance level (differences are considered significant when p < 0,05 (in bold)); OR—odds ratio; CI—confidence interval; AIC—Akaike information criterion