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Table 6 SIRT1 rs3818292, rs3758391, rs7895833 genotypes and alleles frequencies for ON patients with and without MS and control group

From: The role of SIRT1 level and SIRT1 gene polymorphisms in optic neuritis patients with multiple sclerosis

Polymorphism

Genotype

Frequencies, n (proc.)

Control group, n (%)

N = 225

ON patients with MS, n (%)

N = 30

p-value

ON patients with MS, n (%)

N = 43

p-value

rs3818292

Genotype

A/A

192 (85.3)

23 (76.7)

0.243

34 (79.1)

0.250

A/G

28 (12.4)

7 (23.3)

9 (20.9)

G/G

5 (2.2)

0 (0)

0 (0)

Allele

A

412 (91.6)

53 (88.3)

0.408

77 (89.5)

0.544

G

38 (8.4)

7 (11.7)

9 (10.5)

rs3758391

Genotype

C/C

126 (56.0)1

9 (30.0)1

0.023

20 (46.5)

0.270

C/T

81 (36.0)2

17 (56.7)2

21 (48.8)

T/T

18 (8.0)

4 (13.3)

2 (4.7)

Allele

A

333 (74.0)

35 (58.3)

0.011

61 (70.9)

0.554

G

117 (26.0)

25 (41.7)

25 (29.1)

rs7895833

Genotype

A/A

166 (73.8)3

13 (43.4)3

0.001

29 (67.4)

0.107

A/G

47 (20.9)4

16 (53.3)4

14 (32.6)

G/G

12 (5.3)

1 (3.3)

0 (0)

Allele

A

379 (84,2)

42 (70,0)

0.006

72 (83.7)

0.907

G

71 (15,8)

18 (30,0)

14 (16.3)

  1. ON—optical neuritis; MS—multiple sclerosis; p-value—significance level (differences are considered significant, when p < 0,05 (in bold)); 1—p = 0,007; 2—p = 0,029; 3—p = 0,001; 4—p < 0,001