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Table 3 SIRT1 rs3818292, rs3758391, rs7895833 genotypes and alleles frequencies in patients with ON by gender

From: The role of SIRT1 level and SIRT1 gene polymorphisms in optic neuritis patients with multiple sclerosis

Polymorphism

Genotype

Frequency, n (%)

Males

p-value

Females

p-value

Control group,

n (%)

N = 91

Patients with ON, n (%)

N = 26

Control group,

n (%)

N = 134

Patients with ON, n (%)

N = 53

rs3818292

A/A

80 (87.9)

21 (80.8)

0.788

112 (83.6)

41 (77.4)

0.492

A/G

7 (7.7)

5 (19.2)

21 (15.7)

12 (22.6)

G/G

4 (4.4)

0 (0)

1 (0.7)

0 (0)

Allele

A

167 (91.8)

47 (90.4)

0.755

245 (91.4)

94 (88.7)

0.412

G

15 (8.2)

5 (9.6)

23 (8.6)

12 (11.3)

rs3758391

Genotype

C/C

48 (52.7)

10 (38.5)

0.385

78 (58.2)

21 (39.6)

0.056

C/T

32 (35.2)

13 (50)

49 (36.6)

29 (54.7)

T/T

11 (12.1)

3 (11.5)

7 (5.2)

3 (5.7)

Allele

C

128 (70.3)

33 (63.5)

0.346

205 (76.5)

71 (67.0)

0.594

T

54 (29.7)

19 (36.5)

63 (23.5)

35 (33.0)

rs7895833

Genotype

A/A

66 (72.5)

15 (57.7)

0.067

100 (74.6)1

30 (56.6)1

0.014

A/G

19 (20.9)

11 (42.3)

28 (20.9)2

22 (41.5)2

G/G

6 (6.6)

0 (0)

6 (4.5)

1 (1.9)

Allele

A

151 (83.0)

41 (78.8)

0.495

228 (85.1)

82 (77.4)

0.074

G

31 (17.0)

11 (21.2)

40 (14.9)

24 (22.6)

  1. ON—optic neuritis; p-value—significance level (differences are considered significant when p < 0.05, (in bold)); 1—(A/A vs. A/G + G/G) p = 0.022; 2—(A/G vs. A/A + G/G) p = 0.006