Table 2 SIRT1 rs3818292, rs3758391, rs7895833 binary logistic regression between ON and control groups
Polymorphism | Model | Genotype | OR (95% CI) | p-value | AIC |
|---|---|---|---|---|---|
rs3818292 | Codominant | A/A | 1 | 0.064 1 | 345.990 |
A/G | 1.880 (0.865–3.664) | ||||
G/G | – | ||||
Dominant | A/A | 1 | 0.160 | 348.426 | |
A/G + G/G | 1.595 (0.832–3.060) | ||||
Recessive | AA + A/G | 1 | 1 | 347.296 | |
G/G | – | ||||
Overdominant | A/A + G/G | 1 | 0.053 | 346.261 | |
A/G | 1.929 (0.990–3.758) | ||||
Additive | G | 1.275 (0.718–2.264) | 0.407 | 349.667 | |
rs3758391 | Codominant | C/C | 1 | 0.007 0.553 | 344.935 |
C/T | 2.108 (1.226–3.622) | ||||
T/T | 1.355 (0.496–3.698) | ||||
Dominant | C/C | 1 | 0.011 | 343.729 | |
C/T + T/T | 1.971 (1.168–3.324) | ||||
Recessive | C/C + C/T | 1 | 0.909 | 350.322 | |
T/T | 0.945 (0.361–2.473) | ||||
Overdominant | C/C + T/T | 1 | 0.008 | 343.274 | |
C/T | 2.018 (1.201–3.391) | ||||
Additive | T | 1.482 (0.999–2.199) | 0.051 | 346.545 | |
rs7895833 | Codominant | A/A | 1 | 0.001 0.574 | 338.196 |
A/G | 2.590 (1.489–4.506) | ||||
G/G | 0.574 (0.025–7.691) | ||||
Dominant | A/A | 1 | 0.006 | 342.826 | |
A/G + G/G | 2.126 (1.245–3.631) | ||||
Recessive | AA + A/G | 1 | 0.158 | 347.368 | |
G/G | 0.228 (0.029–1.779) | ||||
Overdominant | A/A + G/G | 1 | < 0.001 | 337.908 | |
A/G | 2.717 (1.566–4.712) | ||||
Additive | G | 1.470 (0.950–2.276) | 0.084 | 347.415 |