Table 1 SIRT1 rs3818292, rs3758391, rs7895833 genotypes and alleles frequencies
Polymorphism | Genotype/allele | Frequency (%) | |||
|---|---|---|---|---|---|
Control group, n (%) N = 225 | HWE p-value | Patients with ON, n (%) N = 79 | p-value | ||
rs3818292 | Genotype | ||||
A/A | 192 (85.3) | 0.003 | 62 (78.5) | 0.067 | |
A/G | 28 (12.4) | 17 (21.5) | |||
G/G | 5 (2.2) | 0 (0) | |||
Total | 225 (100) | 79 (100) | |||
Allele | |||||
A | 412 (91.6) | 141 (89.2) | 0.383 | ||
G | 38 (8.4) | 17 (10.8) | |||
rs3758391 | Genotype | ||||
C/C | 126 (56.0)1 | 0.334 | 31 (39.2)1 | 0.024 | |
C/T | 81 (36.0)2 | 42 (53.2)2 | |||
T/T | 18 (8.0) | 6 (7.6) | |||
Total | 225 (100) | 79 (100) | |||
Allele | |||||
C | 333 (74.0) | 104 (65.8) | 0.062 | ||
T | 117 (26.0) | 54 (34.2) | |||
rs7895833 | Genotype | ||||
A/A | 166 (73.8)3 | 0.001 | 45 (57.0)3 | 0.001 | |
A/G | 47 (20.9)4 | 33 (41.8)4 | |||
G/G | 12 (5.3) | 1 (1.3) | |||
Total | 225 (100) | 79 (100) | |||
Allele | |||||
A | 379 (84.2) | 123 (77.8) | 0.069 | ||
G | 71 (15.8) | 35 (22.2) | |||