Fig. 3
From: Multisystem ALK-positive histiocytosis: a multi-case study and literature review
Radiological and pathological features of case 3. A MRI showed multiple patchy and/or nodular abnormal signal shadows in the liver. B The skin biopsy showed dermally infiltrates of histiocytes and Touton cells. C There were numerous foam cells with ALK-positive (inlet) in the mucosal layer of the gallbladder and fibrous tissue hyperplasia in the muscular layer. D The liver lesions showed prominent interstitial sclerosis, accompanied by foamy cells and Touton giant cells. E The histiocytes were positive for CD68 (Skin). F The histiocytes were positive for ALK1 (Skin). (Original magnification × 40 [C]; × 100 [B, D]; × 200 [E, F])