Table 5 Narrative synthesis of included records on the HRQoL in adults with OI
domain | N | Findings | Records |
|---|---|---|---|
Physical function | 28 | Physical functioning was described using a variety of tools however SF-36 (n = 13) was used most often. Included records suggest that physical functioning and independence are lower in adults with OI compared with the overall population. In all included records (n = 4), sleep was affected in individuals with OI | [31, 35, 52, 103, 109, 111, 151, 180, 201, 205, 206, 253,254,255,256,257,258,259,260,261,262,263,264,265,266,267] |
Pain | 7 | Records concluded that adults with OI experienced significantly more pain and pain interference compared with the overall population | |
Fatigue | 5 | Included records concluded that individuals with OI experienced significantly more fatigue compared with the overall population, however women were overrepresented (62–78% of study samples) | |
Mental health | 23 | Included records on the mental health of adults with OI reached conflicting conclusions on the effect of OI on individuals’ mental health | [13, 35, 52, 106, 109, 111, 151, 205, 206, 253,254,255,256,257,258,259,260,261,262, 265,266,267, 270] |
Social functioning | 6 | Records using validated tools (n = 4) found that social functioning of adults with OI was comparable with the overall population |