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Table 5 Mixed-effects models (random intercept and fixed slope) controlling for age and sex

From: Patient-reported outcomes measures of X-linked hypophosphataemia participants: findings from a prospective cohort study in the UK

 

Total sample

 

Total sample

Instrument (n)

Coefficient

p-value

Instrument (n)

Coefficient

p-value

EQ-5D-5L Index score

  

FACIT-F score

  

Intercept

122

0.742

0.000

Intercept

102

107.985

0.000

Time

122

− 0.006

0.483

Time

102

− 2.135

0.038

EQ5D VAS score

  

FACIT-F- physical well-being

  

Intercept

122

63.617

0.000

Intercept

102

19.894

0.000

Time

122

0.445

0.716

Time

102

− 0.038

0.861

EQ5D-3L Index score

  

FACIT-F- social well-being

  

Intercept

122

0.688

0.000

Intercept

102

22.825

0.000

Time

122

− 0.003

0.699

Time

102

− 0.571

0.079

SF-36- physical component score

  

FACIT-F- emotional well-being

  

Intercept

116

41.502

0.000

Intercept

102

14.693

0.000

Time

116

0.242

0.576

Time

102

0.132

0.567

SF-36- mental component score

  

FACIT-F- functional well-being

  

Intercept

116

43.432

0.000

Intercept

102

22.175

0.000

Time

116

− 0.467

0.371

Time

102

− 0.754

0.003

PSQI score

  

FACIT-F- fatigue subscale

  

Intercept

114

7.652

0.000

Intercept

102

28.556

0.000

Time

114

− 0.117

0.473

Time

102

− 0.729

0.136

HADS anxiety score

  

McGill pain score

  

Intercept

96

5.346

0.004

Intercept

115

1.522

0.019

Time

96

0.314

0.031

Time

115

0.011

0.865

HADS depression score

  

Pain detect score

  

Intercept

96

3.385

0.029

Intercept

110

4.977

0.095

Time

96

0.229

0.162

Time

110

0.202

0.464

  1. Time coefficients in bold are statistically significant at a 5% level
  2. EQ-5D-5L (3L), EuroQol 5 dimensions-5 levels (3 levels); VAS, Visual analogue scale; SF-36, Short-form 36; PCS, Physical Component Score; MCS, Mental Component Score; FSS, Fatigue Severity Scale; ESS, Epworth Sleepiness scale; PSQI, Pittsburgh sleep quality index; FACIT-F, Functional assessment of chronic illness therapy-fatigue; SF-MPQ-2, Short form McGill pain questionnaire version 2; HADS, Hospital anxiety and depression scale