Fig. 3
From: Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population
Results of electrophysiological experiments. A–C Representative current traces for CHO cells transfected with (A) KCNQ1/KCNE1 (B) c.1124_1127delTTCA/KCNE1 and (C) KCNQ1/c.1124_1127delTTCA/KCNE1. The voltage protocol is shown on top with below the corresponding current traces. D Current–voltage relationships for KCNQ1/KCNE1 (n = 9, grey symbols) and KCNQ1/c.1124_1127delTTCA/KCNE1 (n = 11, black symbols). Current amplitudes were determined at the end of a 6 s depolarizing step to + 60 mV. Current densities were calculated by dividing the current amplitudes by the cell capacitance. E Voltage-dependence of activation for KCNQ1/KCNE1 (n = 7, grey symbols) and KCNQ1/c.1124_1127delTTCA/KCNE1 (n = 6, black symbols). F Activation kinetics of KCNQ1/KCNE1 (n = 7, grey symbols) and KCNQ1/c.1124_1127delTTCA/KCNE1 (n = 6, black symbols). Shown values are the means ± standard error of mean with n the number of cells analyzed