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Table 3 COX regression model to evaluate risk factors associated with overall survival

From: Systemic amyloidosis journey from diagnosis to outcomes: a twelve-year real-world experience of a single center in a middle-income country

Variable

Univariable

Multivariable¥

HR (95%CI)

p value

HR (95%CI)

p value

Age (years)

1.02 (1.0–1.04)

0.029

–

–

Gender (Female vs. Male*)

0.84 (0.55–1.30)

0.442

–

–

Educational level (elementary vs. secondary/university*)

1.68 (1.01–2.79)

0.044

–

–

ECOG (> 2 vs. < 2*)

1.92 (1.21–3.04)

0.006

1.68 (1.04–2.72)

0.035

Time from symptoms onset to diagnosis (months)

0.99 (0.98–1.0)

0.110

–

–

Number of involved organs (> 2 vs. < 2*)

3.54 (1.91–6.56)

< 0.001

–

–

Cardiac involvement (Yes vs. No*)

4.88 (2.48–9.60)

< 0.001

3.27 (1.55–6.90)

0.020

Kidney involvement (Yes vs. No*)

1.01 (0.66–1.55)

0.967

  

Subtype (AL vs. Non-AL*)#

3.22 (1.77–5.84)

< 0.001

2.44 (1.26–4.72)

0.008

  1. Missing values: educational level (9.0%); ECOG (9.0%)
  2. AL = Light Chain Amyloidosis; CI = Confidence Interval; HR = Hazard Ratio; mo = months; vs. = versus
  3. *Reference
  4. #Inconclusive subtype excluded (n = 9)
  5. ¥Multivariable model (n = 122); C-Index = 0.70