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Table 1 General characteristics of patients by amyloidosis subtype (n = 143)

From: Systemic amyloidosis journey from diagnosis to outcomes: a twelve-year real-world experience of a single center in a middle-income country

Characteristic

Amyloidosis subtype

AL

ATTR

AA

AFib

Inconclusive

n = 97 (%)

n = 19 (%)

n = 12 (%)

n = 6 (%)

n = 9 (%)

Gender

     

 Male

49 (50.5)

15 (78.9)

4 (33.3)

4 (66.7)

5 (55.5)

 Female

48 (49.5)

4(21.1)

8 (66.7)

2 (33.3)

4 (44.4)

Age at diagnosis (years)

     

 Mean (SD)

60.3 (± 11.3)

59.3 (± 15.2)

46.2 (± 16.4)

57.6 (± 5.8)

61.8 (± 15.3)

Educational level

     

 Elementary

58 (67.4)

9 (47.4)

6 (54.5)

3 (50.0)

6 (75.0)

 Secondary

20 (23.2)

8 (42.1)

3 (27.3)

2 (33.3)

2 (25.0)

 University

8 (9.3)

2 (10.5)

2 (18.2)

1 (16.7)

0 (–)

ECOG

     

 > 2

55 (59.1)

16 (94.1)

3 (30.0)

1 (25.0)

8 (100)

 < 2

38 (40.9)

1 (5.9)

7 (70.0)

3 (75.0)

0 (–)

Initial clinical manifestation

     

 Renal disorders

62 (63.9)

2 (10.5)

5 (50.0)

6 (100)

2 (22.2)

 Heart disease

37 (38.1)

12 (63.2)

2 (20.0)

0 (–)

7 (77.7)

 Neuropathy

19 (19.6)

12 (63.2)

2 (20.0)

1 (16.7)

1 (11.1)

 Gastrointestinal symptoms

23 (23.7)

4(21.1)

5 (50.0)

0 (–)

2 (22.2)

 Cachexia

40 (41.2)

6 (31.6)

3 (30.0)

0 (–)

2 (22.2)

Number of specialties consulted until diagnosis

     

 1–2

43 (44.3)

13 (68.4)

3 (25.0)

4 (66.7)

6 (66.7)

 > 3

54 (55.7)

6 (31.6)

9 (75.0)

2 (33.3)

3 (33.3)

Types of specialties consulted until diagnosis

     

 General practitioner

63 (64.9)

9 (47.4)

5 (41.6)

1 (16.7)

4 (44.4)

 Nephrologist

50 (51.5)

2 (10.5)

5 (41.6)

6 (100)

1 (11.1)

 Cardiologist

33 (34.0)

11 (57.9)

2 (16.6)

1 (16.7)

8 (88.8)

 Neurologist

3 (3.1)

10 (52.6)

4 (33.3)

0 (–)

2 (22.2)

 Gastroenterologist

13 (13.4)

3 (15.8)

3 (25.0)

0 (–)

2 (22.2)

Time from symptoms onset to diagnosis (months)

     

 Median (range)

9.0 (0.5–90.3)

30.6 (1.9–108.0)

40 (3.8–74.7)

10.4 (0.9–36.9)

12.4 (2.8–114.0)

  1. Missing values: educational level (9.0%); ECOG (9.0%); time from symptoms onset to diagnosis (4.0%)
  2. AL = Light Chain Amyloidosis, ATTR = Transthyretin Amyloidosis, AA = Serum Amyloid A Amyloidosis, AFib = Fibrinogen Amyloidosis
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172