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Table 2 Average plasma glycine levels comparing high dose benzoate to ketogenic diet with low dose benzoate

From: Ketogenic diet as a glycine lowering therapy in nonketotic hyperglycinemia and impact on brain glycine levels

Patient

Glycine on benzate

N

Glycine on KD

N

Decrease

t-test p

Patient 1

307 ± 41.8

10

197 ± 74.8

10

36%

0.001

Patient 2

321.3 ± 91.5

8

248.3 ± 120

3

23%

0.41

Patient 3

299 ± 27

3

221.7 ± 91

3

26%

0.28

Patient 4

346.3 ± 80.2

34

222.4 ± 83.5

12

36%

0.0003

Patient 5

284.3 ± 80.1

4

191.3 ± 60.3

26

33%

0.01

Patient 6

184.2 ± 33.2

10

159.5 ± 44.1

13

13%

0.16

  1. Comparison of the average glycine levels on high dose benzoate treatment compared to the glycine levels on ketogenic diet with low dose benzoate. N = total number of measurements. Glycine levels within the same patient are compared by a Student t-test, with p values < 0.05 considered significant in bold highlight. A paired Wilcoxon signed rank test comparing the average glycine levels between the two treatment modalities was significant at p = 0.028
  2. Benz, benzoate
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172