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Table 1 Level Type of evidence

From: Patient centered guidelines for the laboratory diagnosis of Gaucher disease type 1

Level

Type of evidence

I

High quality prospective cohort study with adequate power or systematic review of these studies

II

Lesser quality prospective cohort, retrospective cohort study, untreated controls from an RCT, or systematic review of these studies

III

Case–control study or systematic review of these studies

IV

Case series

V

Expert opinion; case report or clinical example; or evidence based on physiology, bench research or “first principles”