From: Patient centered guidelines for the laboratory diagnosis of Gaucher disease type 1
Level | Type of evidence |
---|---|
I | High quality prospective cohort study with adequate power or systematic review of these studies |
II | Lesser quality prospective cohort, retrospective cohort study, untreated controls from an RCT, or systematic review of these studies |
III | Case–control study or systematic review of these studies |
IV | Case series |
V | Expert opinion; case report or clinical example; or evidence based on physiology, bench research or “first principles” |