Table 4 Comparison of pharmacokinetics data of betaine with the litterature

CBS deficiency

Matthews et al. [23]

n = 6

14.5 [6,7,8,9,10,11,12,13,14,15,16,17]^a

100

na

na

11.8 [8.0 – 26.3]^a

0.174 [0.054 – 0.210]^a

na

Current study

n = 5

13.3 [6.8–14.4]^a

100

849 [681–1048]^a

5522 [4909; 9317]^c

16.7 [13.8–20.3]^a

0.15 [0.09–0.17]^a

1.45 [1.2–1.98]^a

250

2074 [1001–2563]^a

13,276 [6454; 14907]^c

12.3 [10.0–16.3]^a

0.16 [0.14–0.33]^a

1.29 [1.15–3.41]^a

cblC/MTHFR deficiency

Schwahn et al. [18]

n = 1

5.8

50

506

1450

6.63

0.297

1.726

n = 1

10.2

50

556

4230

23.2

0.102

1.907

Current study

n = 6

5.4 [1.5–17.8]^a

100

717 [585–1000]^a

7485 [4843; 11907]^a

18.3 [10.9–24.2]^a

0.11 [0.07–0.18]^a

1.56 [1.04–1.86]^a

250

1136 [827–2356]^a

10,389 [7826; 29243]^a

18.4 [9.43–25.9]^a

0.21 [0.07–0.27]^a

2.34 [1.15–3.49]^a