CBS | cblC | CBS | cblC | CBS | cblC | |
---|---|---|---|---|---|---|
100 mg/kg | 100 mg/kg | 250 mg/kg | 250 mg/kg | Ratio 250/100 | Ratio 250/100 | |
N = 5 | N = 5 | N = 5 | N = 6 | N = 6 | N = 6 | |
AUCP,0-48 h,betaine (µmol h/L) | 5522 [4909; 9317] | 7485 [4843; 11907] | 13,276 [6454; 14907] | 10,389 [7826; 29243] | 2.16 [1.30; 2.70] | 1.32 [1.22; 2.46] |
Cmax,betaine (µmol/L) | 849 [681; 1048] | 717 [585; 1000] | 2074 [1001; 2563] | 1136 [827; 2356] | 2.80 [1.47; 3.00] | 1.61 [1.17; 2.36] |
Tmax,betaine (h) | 2 | 2 | 2 | 2 | ||
CLbetaine/F (L/h kg−1) | 0.15 [0.09; 0.17] | 0.11 [0.07; 0.18] | 0.16 [0.14; 0.33] | 0.21 [0.07; 0.27] | ||
Vss,betane/F (L kg−1) | 1.45 [1.2; 1.98] | 1.56 [1.04; 1.86] | 1.29 [1.15; 3.41] | 2.34 [1.15; 3.49] | ||
t1/2, betaine | 16.7 [13.8; 20.3] | 18.3 [10.9; 24.2] | 12.3 [10.0; 16.3] | 18.4 [9.43; 25.9] | ||
AUCP, 0–48 h, DMG (µmol h/L) | 1627 [1149; 2496] | 1408 [669; 2247] | 2269 [1380; 7055] | 2022 [1120; 2470] | 1.51 [1.12; 2.99] | 1.37 [1.08; 1.67] |
Cmax,DMG (µmol/L) | 77.4 [53.6; 169] | 58.2 [31.9; 73.3] | 106 [76.8; 288] | 69.8 [42.1; 125.7] | 1.43 [1.00; 4.12] | 1.32 [1.08; 1.71] |
Tmax,DMG (h) | 6 [6; 24] | 12 [6; 12] | 12 [6; 12] | 12 [6; 48] | ||
t1/2,DMG | 10.5 [8.82; 13.5] | 19.5 [13.9; 25.1] | 8.64 [7.39; 12.5] | 16.0 [10.6; 25.5] |