Fig. 1From: Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8mnd miceSex differences evident in Cln8mnd accumulation of autofluorescent storage material and ATP Synthase subunit C. Cln8mnd males demonstrate greater ASM accumulation within the VPM/VPL at 8 months (A) and within the S1BF at 4 months of age (B). Cln8mnd females show enhanced SubC accumulation at 8 months within the VPM/VPL (C) while no sex differences were detected in the S1BF (D). Two-way ANOVA with Fisher’s LSD post-hoc. Mean ± SEM, n = 2–4 animals/sex/group, detailed n described in Additional file 4: Table S1. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ASM Scale Bar: 200 µm; SubC Scale Bar: 150 µmBack to article page