Skip to main content
Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Sex-split analysis of pathology and motor-behavioral outcomes in a mouse model of CLN8-Batten disease reveals an increased disease burden and trajectory in female Cln8mnd mice

Fig. 1

Sex differences evident in Cln8mnd accumulation of autofluorescent storage material and ATP Synthase subunit C. Cln8mnd males demonstrate greater ASM accumulation within the VPM/VPL at 8 months (A) and within the S1BF at 4 months of age (B). Cln8mnd females show enhanced SubC accumulation at 8 months within the VPM/VPL (C) while no sex differences were detected in the S1BF (D). Two-way ANOVA with Fisher’s LSD post-hoc. Mean ± SEM, n = 2–4 animals/sex/group, detailed n described in Additional file 4: Table S1. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ASM Scale Bar: 200 µm; SubC Scale Bar: 150 µm

Back to article page