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Table 2 Rapid desensitization protocol for laronidase

From: Novel approach to idursulfase and laronidase desensitization in type 2 and type 1 S mucopolysaccharidosis (MPS)

step

solution

minutes

rate (ml/h)

delivered ml

delivered dose (mg)

1

1/100

15

4

1

0.00079

2

1/100

15

10

2.5

0.00197

3

1/100

15

20

5

0.00394

4

1/100

15

40

10

0.0079

5

1/10

15

10

2.5

0.0197

6

1/10

15

20

5

0.0394

7

1/10

15

40

10

0.079

8

1/10

15

80

20

0.158

9

1/1

15

20

5

0.394

10

1/1

15

40

10

0.79

11

1/1

15

80

20

1.58

12

1/1

182

150

455

35.89

total

 

347

  

38.96

  1. Target dose: 39.44 mg (6,800 Units). Dilution 1/100 (bag 1): 10 ml of dilution 1/10-bag 2 in 90 ml of saline (0.00079 mg/ml). Dilution 1/10 (bag 2): 10 ml of dilution 1/1-bag 3 in 90 ml of saline (0.0079 mg/ml). Dilution 1/1 (mother solution; bag 3): 39.44 mg of laronidase in 500 ml of saline (0.079 mg/ml)
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172