Fig. 2

Representative photographs of chronic open RDEB wounds before and after treatment with gene-corrected autologous keratinocyte grafts. Individual 5 × 7 cm gene-corrected grafts denoted by a letter and delineated by blue dots and lines. A One graft was placed on a small wound on subject 2’s back. Investigator global assessment showed 50–74% wound healing compared to baseline at year one, and ≥ 75% healing at years four and five. B One graft applied to a small wound on subject 2’s chest demonstrated ≥ 75% healing through year four, 50–74% at year five, and ≥ 75% from year six onwards. C Four adjacent grafts were placed on subject 7’s upper back. ≥ 75% healing was sustained through year five. D Six contiguous grafts were applied to large, confluent wounds on subject 6’s back. From year one, all showed 50–74% or < 50% healing, likely due to early graft loss