Whole exome sequencing in Brugada and long QT syndromes revealed novel rare and potential pathogenic mutations related to the dysfunction of the cardiac sodium channel

Table 1 The clinical characteristics of patients with Brugada syndrome and long QT syndrome

No	DS	Sex	Age (years)	Onset of age (years)	Ventricular arrhythmia	Symptoms	ICD therapy	Drugs	Familial history
1	Brs	F	40	38	VT	Dizzy, syncope	refused	Beta blocker	No
2	LQTs	F	61	55	VF	Syncope	ICD	Beta blocker	No
3	Brs	M	72	65	VT	Syncope	refused	Beta blocker	Brother (SCD, 31-year-old)
4	Brs	M	48	47	VF	Amaurosis, syncope	ICD	No	No
5	Brs	M	46	45	VT, VF	Dizzy, amaurosis, syncope	ICD	No	No
6	Brs	M	60	57	VT, VF	Syncope	ICD	Beta blocker, mexiletine	No
7	Brs	M	57	47	No	Syncope	refused	No	Three brothers (Brs)
8	Brs	M	41	13	VF	Syncope	ICD	No	No
9	Brs	M	49	47	VT	Palpitation, chest distress	ICD	No	No
10	Brs	M	63	53	EPS induced VF	Dizzy, amaurosis,	ICD	No	No
11	Brs	M	22	22	VF	Syncope	ICD	No	No
12	Brs	F	51	51	VF	Syncope when wake up	ICD	No	No
13	LQTs	F	13	6	Tdp, VF	Sleeping syncope	ICD	Mexiletine	No
14	LQTs	F	19	16	VF	Palpitation, amaurosis, Syncope	ICD	Beta blocker, potassium magnesium aspartate	No
15	Brs	M	41	34	VF	Syncope	ICD	Beta blocker	No
16	Brs	M	54	53	EPS induced VF	Amaurosis, palpitation	ICD	No	No
17	Brs	M	32	31	VT, VF	Syncope, convulsion	ICD	Beta blocker, potassium	No
18	Brs	M	33	23	No	No	ICD	No	No
19	LQTs	F	35	30	VF	Syncope	ICD	Beta blocker	No
20	Brs	M	41	30	VF, AF	Amaurosis, syncope	ICD	No	No
21	LQTs	F	16	14	VF	Amaurosis, syncope	ICD	Beta blocker, pacing rate of 95 bpm	No
22	LQTs	F	16	12	VF	Syncope, chest distress	ICD	No	Mother (SCD, 33-year-old)

DS diseases, M male, F female, AF atrial fibrillation, VT ventricular tachycardia, VF ventricular fibrillation, Tdp torsades de pointes, EPS electrophysiology study, SCD sudden cardiac death, ICD Implantable Cardioverter-Defibrillator,- loss of follow-up or lack of clinical data due to refuse of hospitalization

ISSN: 1750-1172