From: Pearson syndrome: a multisystem mitochondrial disease with bone marrow failure
 | Ying, 2022 (n = 139*) | Reynolds, 2021 (n = 42**) | Yoshimi, 2021 (n = 25) | Rötig, 1995 (n = 21) | |||
---|---|---|---|---|---|---|---|
Symptoms/organ dysfunctions | % | % | average age | % | median age | % | median age |
 |  |  | (months) |  | (range, months) |  | (range, months) |
Failure to thrive | 49 | 89 | – | 72 | 12 (3–92) | – | – |
Muscle hypotonia | 12 | 71 | – | 52 | 24 (7–77) | – | – |
Pancreatic insufficiency | 40 | 47 | 20 | 56 | 12 (3–31) | 57 | 12 (5–42) |
Liver dysfunction | - | 66 | 8 | 16 | 18 (10–30) | 33 | 23 (7–36) |
Renal disorders | 43 | 80 | – | – | – | – | – |
(tubulopathy/Fanconi syndrome) | - | 37 | 48 | 32 | 41 (21–121) | 24 | 30 (23–45) |
Cardiac abnormality/arrhythmia | 20 | 66 |  | 20 | 66 (31–183) | – | – |
(cardiac conduction diseases) | – | (17) | (107) | – | – | – | – |
Adrenal insufficiency | – | 30 | 57 | 8 | 66 (65–67) |  |  |
Diabetes mellitus | 18 | 22 | 111 | 4 | 19 | 10 | 30 (24–36) |
Ophthalmological problem | 24 | 86 | – | 20 | 39 (19–92) | – | – |
Hearing impairment | 3 | 31 | 100 | 4 | 115 | Â | Â |