Fig. 1From: Pearson syndrome: a multisystem mitochondrial disease with bone marrow failureHypothesis for the phenotypical change in Pearson syndrome. Hematological recovery is hypothesized to be due to a positive selection of hematopoietic stem cells harboring low load of deleted mitochondrial DNA (mtDNA). In contrast, deleted mtDNA accumulates in muscle, resulting in the development of Kearns-Sayre syndrome with muscular complicationsBack to article page