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Table 4 The various drug price calculation methods applied

From: The actual status of drug prices and adjustment factors for drug price calculation: an analysis of ultra-orphan drug development in Japan

Drug price calculation method

Ultra-orphan drugs

Orphan drugs

Non-orphan drugs

All

35

(100%)

81

(100%)

277

(100%)

Similar efficacy comparison method (I)

11

(31.4%)

51

(63.0%)

176

(63.5%)

Similar efficacy comparison method (II)

0

(0%)

3

(3.7%)

34

(12.3%)

Cost accounting method

24

(68.6%)

27

(33.3%)

63

(22.7%)

Special provisions for new medical combination drugs

0

(0%)

0

(0%)

2

(0.7%)

Special provisions for new drugs for which racemic or prior products exist

0

(0%)

0

(0%)

1

(0.4%)

Special provisions for new drugs that are optically split from a previously-listed drug (racemic)

0

(0%)

0

(0%)

1

(0.4%)