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Table 1 Examples of drug price adjustment

From: The actual status of drug prices and adjustment factors for drug price calculation: an analysis of ultra-orphan drug development in Japan

Trade name/Generic name

Tepmetko Tablets 250 mg/Tepotinib Hydrochloride Hydrate

Crysvita Subcutaneous Injection 10 mg 1 mL/Burosumab (Genetical Recombination)

Drug price calculation method

Similar efficacy comparison method (I)

Cost accounting method (new)

Price before adjustment (A)

12,520.90 JPY

155,774.00 JPY

Premium for usefulness-based group (B)

5

45

Premium for marketability-based group (C)

0

10

Premium for Sakigake Designation Scheme (D)

10

0

Addition factor*1 (E)

1.0

Foreign average price adjustment*2 (F)

1

1.26245

Calculation Formula

A × (1 + (B + C + D)/100) × F

A × (1 + (B + C + D)/100 × E) × F

Price

14,399.00 JPY

304,818.00 JPY

  1. *1 Factor used in the case of the cost accounting method (new), depending on the degree of disclosure of total product cost. *2 Calculated as 1 if there is no adjustment