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Fig. 7 | Orphanet Journal of Rare Diseases

Fig. 7

From: Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs

Fig. 7

Identification of LYVE-1 as a down-regulated gene in vitro and in vivo. A, Expression of LYVE-1 in resFOP-ML and FOP-ML. Cells were treated with or without Activin-A for 12 h, and stained by anti-CD14, anti-LYVE-1 antibodies and DAPI. Scale bar = 50 μm. B, Expression of LYVE-1 in monocytes localized in HO lesions. Tissues were taken from collagenase injected sites (WT) or pinch-injured sites (FOP) and stained with H&E or Safranin-O. The expression of LYVE-1 in monocytes/macrophages localized adjacent to the HO site (white rectangles) was analyzed by anti-LYVE-1 antibody along with anti-F4/80 antibody and DAPI. The samples were collected from three biologically independent experiments. Scale bar = 250 μm

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172