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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: A novel loss-of-function mutation of the voltage-gated potassium channel Kv10.2 involved in epilepsy and autism

Fig. 1

Electrophysiological properties of WT and N856H Kv10.2 channels expressed in COS7 cells. A Current recordings obtained in COS7 cells transfected with WT or N856H Kv10.2, as indicated, after applying the pulse protocol shown on the top. B Current–voltage relationship obtained after plotting the amplitude of the current measured at the end of the 3-s pulses versus membrane potential, as in A. C Normalised current recordings obtained after depolarising cells expressing WT or N856H from −80 mV to + 50 mV. D Time constant of activation of WT or N856H at + 50 mV. E Voltage dependence of the time constant of activation of WT or N856H. n = 12 for WT Kv10.2, n = 11 for N856H Kv10.2. *p < 0.05, **p < 0.01, ***p < 0.001

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172