Table 2 Performance of selected algorithms to identify individuals with NF1
Algorithm | True positive | True negative | False negative | False positive | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|---|---|---|
EMR search | 60 | 273,354 | 11 | 15 | 85 (74–92) | 100 (100–100) | 80 (69–88) | 100 (100–100) |
Billing algorithms | ||||||||
CIHI | 15 | 273,325 | 56 | 6 | 21 (12–31) | 100 (100–100) | 71 (52–91) | 100 (100–100) |
CIHI or NARCS or SDS | 22 | 273,321 | 49 | 10 | 31 (20–42) | 100 (100–100) | 69 (53–85) | 100 (100–100) |
1 OHIP ever | 65 | 125,703 | 6 | 147,628 | 92 (85–98) | 46 (46–46) | 0 (0–0.1) | 100 (100–100) |
CIHI or 2 OHIP* ever | 58 | 218,349 | 13 | 54,982 | 82 (73–91) | 80 (80–80) | 0.1 (0.1–0.1) | 100 (100–100) |
CIHI or 4 OHIP in 3 y | 45 | 246,079 | 26 | 27,252 | 90 (90–90) | 63 (52–75) | 0.2 (0.1–0.2) | 100 (100–100) |
OHIP 225 & OHIP 758* ever | 6 | 273,319 | 65 | 12 | 9 (2–15) | 100 (100–100) | 33 (12–55) | 100 (100–100) |
CIHI or 2 OHIP* ever | 55 | 221,560 | 16 | 51,771 | 70 (58–80) | 81 (91–81) | 0.1 (0.1–0.2) | 100 (100–100) |