Table 1 Basic data and bias in the included studies
From: Efficacy of ketogenic diet in CDKL5-related epilepsy: a single arm meta-analysis
Included studies | Type of studies | Cases | Median age of KD initiation | Intervention | Time of Follow-up | Outcomes | Responder rate% | NOS | ||
|---|---|---|---|---|---|---|---|---|---|---|
(Cohort) | T | C | (Median) | (n/N) | ||||||
Amin [23] | Retrospective | 23 | 22 months | KD | – | 2 years | Only described effective (parent questionnaire) | 52.2(12/23) | 5 | |
Ko [26] | Retrospective | 9 | Not mentioned | KD | – | Not mentioned | Only described effective | 11.1(1/9) | 3 | |
Ko [25] | Retrospective | 10 | Not mentioned | KD | – | ≥ 12 months | Seizure reduction ≥ 90% | 0(0/10) | 5 | |
Kobayashi [27] | Retrospective | 10 | Not mentioned | KD | – | Not mentioned | Seizure reduction ≥ 50% | 10.0(1/10) | 4 | |
Lim [19] | Retrospective | 104 | Not mentioned | KD | – | 17 months | Only described effective (parent questionnaire) | 58.7(61/104) | 5 | |
Moseley [8] | Retrospective | 6 | Not mentioned | KD | – | Not mentioned | Only described effective (parent questionnaire) | 50.0(3/6) | 4 | |
Müller [22] | Retrospective | 12 | Not mentioned | KD | – | ≥ 3 months | Seizure reduction ≥ 50% in last 4 weeks | 16.7(2/12) | 5 | |
Neupauerová [24] | Retrospective | 2 | 3 years | KD | – | Not mentioned | Seizure reduction ≥ 50% | 50.0(1/2) | 4 | |
Siri [28] | Retrospective | 5 | Not mentioned | KD | – | Not mentioned | Only described effective | 20.0(1/5) | 3 | |
Hu [29] | Retrospective | 4 | Not mentioned | KD | – | Not mentioned | Only described effective | 25.0(1/4) | 3 | |
Xiong [30] | Retrospective | 5 | Not mentioned | KD | – | Not mentioned | Only described effective | 40.0(2/5) | 3 | |
Mei [31] | Retrospective | 3 | Not mentioned | KD | – | Not mentioned | Only described effective | 66.7%(2/3) | 3 | |